| Test name | Test name | Week 1 | Week 2 | Week 3 | Convalescent |
| Test brand | Test brand |
Test groups (true positives/COVID cases) Sensitivity (95% CI) |
|||
| Assays targeting IgA alone | |||||
| ELISA | |||||
| Euroimmun | Anti‐SARS‐COV‐2 IgA | 19 (260/587) | 18 (490/660) | 16 (334/385) | 17 (866/989) |
| 44.0 (34.0, 54.6) |
76.7 (69.8, 82.4) |
92.7 (85.0, 96.6) |
87.7 (84.5, 90.3) |
||
| Gold Standard Diagnostics | Gold Standard SARS‐CoV‐2 IgA ELISA | 1 (18/123) | |||
| 14.6a (8.9, 22.1)* |
|||||
| Mediagnost | Mediagnost Anti‐SARS‐CoV‐2 ELISA IgA | 1 (28/46) | |||
| 60.9a (45.4, 74.9)* |
|||||
| RayBiotech | Covid‐19 human ELISA IgA | 1 (1/35) | |||
| 2.9a (0.1, 14.9)* |
|||||
| CLIA | |||||
| Beijing Wantai | Wantai CLIA IgA assay | 1 (18/31) | 1 (25/29) | 1 (36/38) | 1 (39/47) |
| 58.1a (39.1, 75.5)* |
86.2a (68.3, 96.1)* |
94.7a (82.3, 99.4)* |
83.0a (69.2, 92.4)* |
||
| Other/unclear | |||||
| Genalyte | Maverick SARS‐CoV‐2 Multi‐Antigen Serology Panel IgA (S‐based) | 1 (15/48) | 1 (41/81) | 1 (28/39) | 1 (6/26) |
| 31.2 (18.7, 46.3) | 50.6 (39.3, 61.9) | 71.8 (55.1, 85.0) | 23.1 (9.0, 43.6) | ||
| Genalyte | Maverick SARS‐CoV‐2 Multi‐Antigen Serology Panel IgA (N‐based) | 1 (11/48) | 1 (42/81) | 1 (26/39) | |
| 22.9 (12.0, 37.3) | 51.9 (40.5, 63.1) | 66.7 (49.8, 80.9) | 1 (2/26) | ||
| Vibrant America | Vibrant COVID‐19 Ab IgA | 1 (220/330) | 1 (276/330) | 7.7 (0.9, 25.1) | |
| 66.7a (61.3, 71.7)* |
83.6a (79.2, 87.5)* |
||||
| Assays targeting IgA or IgG | |||||
| Euroimmun | anti‐SARS‐COV‐2 IgA/IgG ELISA | 6 (87/167) | 5 (141/170) | 5 (118/125) | 4 (149/157) |
| 49.6 (35.1, 64.0) |
82.9 (76.5, 87.9) |
94.4 (88.7, 97.3) |
94.9 (90.1, 97.4) |
||
| Assays targeting IgA or IgM | |||||
| Vircell | COVID‐19 ELISA IgM+IgA | 1 (49/52) | 1 (36/36) | 1 (43/44) | |
| 94.2a (84.1, 98.8)* |
100a (90.3, 100)** |
97.7a (88.0, 99.9)* |
|||
|
aEstimates and confidence intervals by summing the counts of true positive and false negative across 2 x 2 tables *95% exact binomial confidence interval **97.5% one‐sided exact binomial confidence interval Ab: antibodyCI: confidence intervals CGIA: colloidal gold immunoassayCLIA: chemiluminescence immunoassay DNA: deoxyribonucleic acidELISA: enzyme‐linked immunosorbent assay FIA: fluorescence immunoassay LFA: lateral flow assayMIA: magnetic immunoassay RT‐PCR: reverse transcription polymerase chain reaction | |||||
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