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. 2022 Nov 3;12:1009548. doi: 10.3389/fonc.2022.1009548

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Copyright © 2022 Aoki, Han, Tome, Yamamoto, Kubota, Masaki, Obara, Hamada, Wang, Inubushi, Bouvet, Clarke, Nishida and Hoffman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methionine-independent revertant osteosarcoma cells have reduced tumor growth and lost metastatic potential, in orthotopic xenograft mouse models. (A–C) Tumor growth in the orthotopic xenograft mouse models of 143B-P or 143B-R cells. Dashed yellow lines show the edge of the tumor tissue. Scale bar: 50 mm. *P < 0.05. (D) Representative photomicrographs of H&E-stained primary tumor tissues in the tibia of 143B-P and 143B-R cells. Scale bar: 100 μm. Magnification: 100×. (E) Spontaneous lung metastases from the tibia of 143B-P and 143B-R cells. Dashed yellow lines show metastatic lesions in the lung. Scale bar in photographs: 25 mm. Scale bar in photomicrographs: 500 μm. Magnification of photomicrographs: 40×. 143B-P: methionine-addicted parental 143B osteosarcoma cells, 143B-R: methionine-independent 143B osteosarcoma cells.