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. 2022 Nov 3;9:887678. doi: 10.3389/fmolb.2022.887678

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Copyright © 2022 Calero, Moleiro, Sayd, Dorca, Miquel-Rio, Paz, Robledo-Montaña, Enciso, Acción, Herráez-Aguilar, Hellweg, Sánchez, Bortolozzi, Leza, García-Bueno and Monroy.

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Uptake of GR@LNPs by parenchymal microglia. Representative immunofluorescences of 6-FAM-labeled GR@LNPs (green in panels B,F, and J), iba1+ parenchymal microglia (red in panels A,E, and I), and nuclear DAPI (blue in panels C,G, and K) in rat prefrontal cortex sections from control rats treated with GR-free@LNP (panels A–D), animals treated with GR1 and GR2-antisense @LNPs (panels E–H), and negative control rats treated with GR3-nonsense@LNPs (panels I–L). White head arrows and magnifications in merge images (panels D,H, and L) show a lack of co-localizations of GR@LNPs with parenchymal microglia in the different experimental groups studied. On the contrary, yellow arrows in H and L show a 6-FAM signal in perivascular and meningeal locations, respectively. Scale bars = 15 μm.