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. 2022 Nov 3;9:887678. doi: 10.3389/fmolb.2022.887678

FIGURE 12.

FIGURE 12

Single administration of GR1 and GR2-antisense@LNP reduces PGDS mRNA expression in peripheral locations of the rat prefrontal cortex (PFC). Rats received intracerebroventricularly (ICV) 25 μL of i GR-free@LNP, ii) GR3-nonsense@LNP, or iii) GR1&GR2-antisense@LNP (total GR concentration estimated at 0.15 nmol/μL) and were euthanized at 1-week post-infusion (n = 3 rats/group). (A) Representative coronal brain sections of the prefrontal cortex showing PGDS mRNA levels in brain borderlines. The frames inserted in the images show enlargements from the prefrontal cortex of rats. Scale bars: 1 mm (upper panels) and 0.5 mm (lower panels). (B) Significant reductions of PGDS mRNA expression in the medial and lateral edges of the prefrontal cortex of GR1 and GR2-antisense@LNP‐injected rats compared to control rats injected with GR-free@LNP or GR3-nonsense@LNP. The values are presented as mean ± SEM. *p < 0.05 and **p < 0.01, compared to control groups.