Table 2. Simple logistic regression analysis to determine factors associated with methotrexate treatment success (N=73).
POD: Pouch of Douglas; MTX: Methotrexate; β-hCG: beta-human Chorionic Gonadotropin; C-Section: Cesarean section delivery.
| Characteristic | Fail, n=9 n (%) | Successful, n=64 n (%) | Crude OR (95% CI) | P-value |
| Sociodemographic | ||||
| Age (years) | 29.00 (5.17) | 30.91 (5.14) | 1.08 (09.4, 1.24) | 0.300 |
| Ethnicity | ||||
| Malay | 5 (10.6) | 42 (89.4) | Ref | |
| Non-Malay | 4 (15.4) | 22 (84.6) | 0.66 (0.16, 2.69) | 0.557 |
| Current obstetric history | ||||
| Gravida | ||||
| 1 | 1 (6.3) | 15 (93.8) | Ref | |
| 2 | 4 (16.0) | 21 (84.0) | 0.35 (0.04, 3.45) | 0.369 |
| 3 | 1 (12.5) | 7 (87.5) | 0.47 (0.03, 8.60) | 0.608 |
| 4 | 1 (10.0) | 9 (90.0) | 0.60 (0.03, 10.82) | 0.729 |
| > 5 | 2 (14.3) | 12 (95.7) | 0.40 (0.03, 4.96) | 0.476 |
| Parity | ||||
| 0 | 4 (14.3) | 24 (85.7) | Ref | |
| 1 | 2 (9.1) | 20 (90.9) | 1.67 (0.28, 10.06) | 0.578 |
| 2 | 1 (9.1) | 10 (90.2) | 1.67 (0.17, 16.83) | 0.665 |
| 3 or more | 2 (16.7) | 10 (83.3) | 0.83 (0.13, 5.30) | 0.847 |
| Gestational age (weeks) | 7.33 (1.66) | 7.26 (2.13) | 0.98 (0.71, 1.37) | 0.926 |
| Location of ectopic pregnancy | ||||
| Tubal | 7 (14.6) | 41 (85.4) | Ref | |
| Cesarean scar | 2 (11.8) | 15 (88.2) | 1.28 (0.24, 6.86) | 0.773 |
| Cornual or Cervical | 0 (0.0) | 8 (100.0) | Unable to calculate | |
| Size of ectopic pregnancy | ||||
| < 3.5 cm | 4 (6.3) | 60 (93.8) | 18.75 (3.57, 98.54) | 0.001 |
| > 3.5 cm | 5 (55.6) | 4 (44.4) | Ref | |
| Yolk sac | ||||
| Absent | 0 (0.0) | 40 (100.0) | Ref | |
| Present | 9 (27.3) | 24 (72.7) | Unable to calculate | |
| Fetal cardiac activities | ||||
| Absent | 6 (9.8) | 55 (90.2) | 3.06 (0.65, 14.47) | 0.159 |
| Present | 3 (25.0) | 9 (75.0) | Ref | |
| Free fluid at POD | ||||
| Absent | 2 (3.6) | 54 (96.4) | 18.90 (3.42, 104.52) | 0.001 |
| Present | 7 (41.2) | 10 (58.8) | Ref | |
| Route of MTX | ||||
| Intramuscular | 7 (13.5) | 45 (86.5) | Ref | |
| Transvaginal/ Transcervical | 2 (10.0) | 18 (90.0) | 1.40 (0.27, 7.39) | 0.692 |
| Laparoscopic | 0 (0.0) | 1 (100.0) | Unable to calculate | |
| Baseline b-hCG level | ||||
| < 1500 | 1 (10.0) | 9 (90.0) | Ref | |
| 1500 – 4999 | 5 (11.9) | 37 (88.1) | 0.82 (0.09, 7.94) | 0.866 |
| 5000 – 9999 | 1 (20.0) | 4 (80.0) | 0.44 (0.02, 9.03) | 0.598 |
| > 10,000 | 2 (12.5) | 14 (87.5) | 0.78 (0.06, 9.89) | 0.846 |
| Past obstetric history | ||||
| Previous abortion | ||||
| No | 6 (13.3) | 39 (86.7) | 0.78 (0.18, 3.41) | 0.741 |
| Yes | 3 (10.7) | 25 (89.3) | Ref | |
| Previous ectopic pregnancy | ||||
| No | 7 (11.1) | 56 (88.9) | 2.00 (0.35, 11.36) | 0.434 |
| Yes | 2 (20.0) | 8 (80.0) | Ref | |
| History of infertility | ||||
| No | 7 (10.4) | 60 (89.6) | 4.29 (0.66, 27.79) | 0.127 |
| Yes | 2 (33.3) | 4 (66.7) | Ref | |
| Past gynecology history | ||||
| Previous tubal surgery | ||||
| No | 7 (10.9) | 57 (89.1) | 2.33 (0.40, 13.48) | 0.346 |
| Yes | 2 (22.2) | 7 (77.8) | Ref | |
| History of C-Section | ||||
| No | 7 (14.6) | 41 (85.4) | 0.51 (0.10, 2.66) | 0.424 |
| Yes | 2 (8.0) | 23 (92.0) | Ref |