Table 4. Simple logistic regression analysis to determine factors associated with first-dose methotrexate treatment success (N=64).
POD: Pouch of Douglas; MTX: Methotrexate; β-hCG: beta-human Chorionic Gonadotropin; C-Section: Cesarean section delivery.
| Characteristic | Success second dose (n=8) n (%) | Success first dose MTX (n=56) n (%) | Crude OR (95% CI) | P-value |
| Sociodemographic | ||||
| Age (years) | 31.88 (6.31) | 30.77 (5.01) | 0.96 (0.83, 1.11) | 0.567 |
| Ethnicity | ||||
| Malay | 5 (11.9) | 37 (88.1) | Ref | |
| Non-Malay | 3 (13.6) | 19 (86.4) | 0.66 (0.16, 2.69) | 0.557 |
| Current obstetric history | ||||
| Gravida | ||||
| 1 | 2 (13.3) | 13 (86.7) | Ref | |
| 2 | 1 (4.8) | 20 (95.2) | 3.08 (0.25, 37.48) | 0.378 |
| 3 | 2 (28.6) | 5 (71.4) | 0.39 (0.04, 3.52) | 0.385 |
| 4 | 0 (0.0) | 9 (100.0) | Unable to calculate | - |
| > 5 | 3 (25.0) | 9 (75.0) | 0.46 (0.06, 3.35) | 0.444 |
| Parity | ||||
| 0 | 3 (12.5) | 21 (97.5) | Ref | |
| 1 | 2 (10.0) | 18 (90.0) | 1.29 (0.19, 8.57) | 0.795 |
| 2 | 2 (20.0) | 8 (80.0) | 0.57 (0.08, 4.08) | 0.577 |
| 3 or more | 1 (10.0) | 9 (90.0) | 1.29 (1.12, 14.09) | 0.837 |
| Gestational age (weeks) | 7.75 (3.20) | 7.20 (1.97) | 0.90 (0.66, 1.27) | 0.493 |
| Location of ectopic pregnancy | ||||
| Tubal | 4 (9.8) | 37 (90.2) | Ref | |
| Cesarean scar | 2 (13.3) | 13 (86.7) | 0.70 (1.12, 4.30) | 0.703 |
| Cornual or Cervical | 2 (25.0) | 6 (75.0) | 0.32 (0.05, 2.18) | 0.246 |
| Size of ectopic pregnancy | ||||
| < 3.5 cm | 7 (11.7) | 53 (88.3) | 2.52 (0.23, 27.72) | 0.449 |
| > 3.5 cm | 1 (25.0) | 3 (75.0) | Ref | |
| Yolk sac | ||||
| Absent | 2 (5.0) | 38 (95.0) | 6.33 (1.16, 34.52) | 0.033 |
| Present | 6 (25.0) | 18 (75.0) | Ref | |
| Fetal cardiac activities | ||||
| Absent | 4 (7.3) | 51 (92.7) | 10.20 (1.93, 53.79) | 0.006 |
| Present | 4 (44.4) | 5 (55.6) | Ref | |
| Free fluid at POD | ||||
| Absent | 6 (11.1) | 48 (88.9) | 2.00 (0.34, 11.70) | 0.442 |
| Present | 2 (20.0) | 8 (80.0) | Ref | |
| Route of MTX | ||||
| Intramuscular | 4 (8.9) | 41 (91.1) | ref | |
| Transvaginal/ Transcervical | 3 (16.7) | 15 (83.3) | 0.48 (0.10, 2.44) | 0.382 |
| Laparoscopic | 1 (100.0) | 0 (0.0) | Unable to calculate | |
| Baseline b-hCG level | ||||
| < 1500 | 1 (11.1) | 8 (88.9) | Ref | |
| 1500 – 4999 | 3 (8.1) | 34 (91.9) | 1.14 (0.13, 15.47) | 0.775 |
| 5000 – 9999 | 1 (25.0) | 3 (75.0) | 0.38 (0.02, 8.10) | 0.532 |
| > 10,000 | 3 (21.4) | 11 (78.6) | 0.46 (0.04, 5.27) | 0.531 |
| Past obstetric history | ||||
| Previous abortion | ||||
| No | 3 (7.7) | 36 (92.3) | 3.00 (0.65, 13.89) | 0.160 |
| Yes | 5 (20.0) | 20 (80.0) | Ref | |
| Previous ectopic pregnancy | ||||
| No | 8 (14.3) | 48 (85.7) | Unable to calculate | - |
| Yes | 0 (0.0) | 8 (100.0) | Ref | |
| History of infertility | ||||
| No | 7 (11.7) | 53 (88.3) | 2.52 (0.23, 27.72) | 0.449 |
| Yes | 1 (25.0) | 3 (75.0) | Ref | |
| Past gynecology history | ||||
| Previous tubal surgery | ||||
| No | 8 (14.0) | 49 (86.0) | Unable to calculate | - |
| Yes | 0 (0.0) | 7 (100.0) | Ref | |
| History of C-Section | ||||
| No | 6 (14.6) | 35 (85.4) | 0.56 (0.10, 3.01) | 0.495 |
| Yes | 2 (8.7) | 21 (91.3) | Ref |