Table 2. Characteristics of the selected SNPs.
| SNP | Gene/Gene Product | Chromosome | Reference Allele | Polymorphic Allele | MAF | Consequence | Effect of pain / analgesia |
|---|---|---|---|---|---|---|---|
| rs4818 |
COMT Catechol-O-methyltransferase |
22 | C | G | 0.29 | Synonymous Variant | Intensity, sensitivity and duration of pain [11,12]. |
| rs6269 |
COMT Catechol-O-methyltransferase |
22 | A | G | 0.37 | Intron Variant | Pain sensitivity and opioid efficacy post-surgical pain [12,13]. |
| rs3783641 |
GCH1 GTP cyclohydrolase 1 |
14 | T | A | 0.22 | Intron Variant | Modulates pain sensitivity [14]. |
| rs6276 |
DRD2 Dopamine Receptor D2 |
11 | C | T | 0.46 | 3 Prime UTR Variant | Significant association with pain scores [15]. |
| rs1799971 |
OPRM1 Opioid receptor mu 1 |
6 | A | G | 0.22 | Missense variant | Enhanced sensitivity for physical pain perception [16,17]. |
| rs6795970 |
SCN10A Sodium voltage-gated channel alpha subunit 10 |
3 | G | A | 0.25 | Missense variant | Modulates pain sensitivity [18]. Higher risk for inadequate analgesia [19]. |
| rs6746030 |
SCN9A Sodium voltage-gated channel alpha subunit 9 |
2 | G | A | 0.12 | Missense variant | Associated with variability of basal pain sensitivity [20]. |