Table 4. Summary of the PheWAS results of p-values below 0.05 for each SNP separately, using the total sample, and the groups that received more and less anesthesia, considering sex and ethnicity.

* Indicates statistically significant results after correction for multiple testing.

Phenotype	Phecode	SNP/Allele	Odds Ratio (95% Confidence Interval)	P-value	Affected	Non affected	Allele frequency
Total sample
Gingival and periodontal diseases	523	rs1799971_G	0.61 (0.35–0.97)	0.05	105	1171	0.13
Periodontitis (acute or chronic)	523.3	rs1799971_G	0.64 (0.44–0.9)	0.01	195	1081	0.13
Leukoplakia of oral mucosa	528.6	rs1799971_G	1.28 (1.02–1.61)	0.03	467	809	0.13
Asthma	495	rs1799971_G	0.44 (0.27–0.69)	0.0006*	154	1118	0.13
Spontaneous ecchymoses	287.1	rs1799971_G	0.47 (0.24–0.83)	0.02	86	1187	0.13
Hypertension	401	rs1799971_G	0.63 (0.46–0.85)	0.003	302	971	0.13
Females—more anesthesia
Gingival and periodontal diseases	523	rs3783641_A	1.82 (1.08–3.02)	0.02	40	465	0.21
Chronic periodontitis	523.32	rs3783641_A	0.18 (0.03–0.61)	0.02	20	485	0.21
Disturbance of salivary secretion	527.7	rs3783641_A	0.39 (0.22–0.64)	0.0005*	80	425	0.21
Whites—less anesthesia
Gingival and periodontal diseases	523	rs1799971_G	0.22 (0.04–0.71)	0.04	32	262	0.12
Periodontitis (acute or chronic)	523.3	rs1799971_G	0.17 (0.05–0.43)	0.0008*	69	225	0.12
Blacks—less anesthesia
Diseases and other conditions of the tongue	529	rs4818_G	5.08 (1.87–15.97)	0.002*	37	33	0.2