TABLE 1.
Type-specific antibodies in sera after immunization with PPS and PNC
| Type | Vaccine (dose [μg]) | Route | Adjuvant | Geometric mean titer (EU/ml)a of:
|
||
|---|---|---|---|---|---|---|
| IgG | IgM | IgA | ||||
| Type 1 | ||||||
| A | PNC-1 (0.5) | i.n. | RV | 771 (384–1550) | 40 (26–62) | 42 (29–62) |
| B | PNC-1 (2.0) | i.n. | RV | 5,365 (2,720–10,583) | 55 (33–91) | 341 (207–564) |
| C | PPS-1 (2.0) | i.n. | RV | 38 (11–125) | 71 (47–106) | 52 (37–72) |
| D | PNC-1 (0.5) | i.n. | Saline | 33 (15–74) | 11 (5–24) | 26 (21–33) |
| E | PNC-1 (2.0) | i.n. | Saline | 220 (132–371) | 23 (13–43) | 49 (28–85) |
| F | PPS-1 (2.0) | i.n. | Saline | 7 (5–11) | 33 (22–48) | 45 (28–72) |
| G | PNC-1 (0.5) | s.c. | Saline | 2,562 (882–7,441) | 99 (31–312) | 62 (40–95) |
| H | Control | 3 (3–4) | 17 (10–28) | 28 (20–42) | ||
| Type 3 | ||||||
| A | PNC-3 (2.0) | i.n. | RV | 48 (12–193) | 68 (50–92) | |
| B | PPS-3 (2.0) | i.n. | RV | 5 (4–6) | 49 (34–70) | |
| C | PNC-3 (2.0) | i.n. | Saline | 3 (1–6) | 37 (15–78) | |
| D | PPS-3 (2.0) | i.n. | Saline | 4 (3–8) | 44 (16–121) | |
| E | PNC-3 (2.0) | i.p. | FCA or FIA | 1,650 (1,131–2,407) | 147 (67–327) | |
| F | Control | 2 (2–3) | 38 (15–97) | |||
a
The 95% confidence interval is given in parentheses.