Table 3.
Results of meta-regression analysis.
| Variable included in univariate analysis (number of studies) |
Coefficient (95%Confidence interval) |
p-value | I2-residual (%) | R2 | |
|---|---|---|---|---|---|
| Age (year) (19) | .0037202 (−0.0249393 0.0323796) |
0.787 | 89.51 | −6.29 | |
| Gender (male-%) (19) | −0.0125623 (−0.0315228 0.0063982) |
0.180 | 89.36 | 5.54 | |
| Total participants (n) (19) | −1.88e-06 (−8.02e-06 4.27e-06) |
0.528 | 89.13 | −4.67 | |
| BMI (kg/m2) (6) | .0123467 (−0.3903656 0.415059) |
0.936 | 75.39 | −32.18 | |
| Obesity (%) (5) | −0.0140209 (−0.0502218 0.0221799) |
0.306 | 70.51 | 13.30 | |
| CVD (%) (18) | −0.004839 (−0.0247176 0.0150395) |
0.613 | 90.51 | −4.45 | |
| Hypertension (%) (19) | −0.0174232 (−0.0296499 −0.0051965) |
0.008 | 85.85 | 39.06 | |
| Diabetes (%) (17) | −0.0206864 (−0.037172 −0.0042008) |
0.017 | 87.64 | 33.14 | |
| CKD (%) (13) | −0.042925 (−0.0809309 −0.0049191) |
0.030 | 61.20 | 46.72 | |
| Hyperlipidemia (%) (7) | −0.0120645 (−0.0284748 0.0043457) |
0.117 | 49.07 | 48.57 | |
| Smoke (%) (7) | .0322809 (−0.0385474 0.1031091) |
0.294 | 61.35 | 11.80 | |
| NOS (score) (19) | −0.1787508 (−0.7542938 0.3967923) |
0.521 | 89.09 | −1.04 | |
| RAAS – inhibitors use (%) (7) | −0.0078018 (−0.0220101 0.0064065) |
0.217 | 39.08 | 21.55 | |
| Stringency index (unit) (19) | .0014277 (−0.0123503 0.0152056) |
0.830 | 88.81 | −5.37 | |
| Fatality rate (%) (19) | .0121743 (−0.0674449 0.0917934) |
0.751 | 89.96 | −6.17 | |
| Reproduction rate (unit) (19) | −0.0856447 (−0.4453866 0.2740973) |
0.622 | 89.99 | −4.31 | |
| New cases per 1 M (n) (19) | −0.0050174 (−0.0117136 0.0016789) |
0.132 | 87.06 | 10.58 | |
| Hospitalized patients per 1 M (n) (6) | −0.0001298 (−0.0053418 0.0050822) |
0.948 | 84.14 | −42.08 | |
| Mortality (day) (7) | −0.115428 (−0.2602414 0.0293854) |
0.096 | 64.92 | 42.28 | |
| Multivariate analysis (12) | |||||
| Hypertension | .0161822 (−0.0126633 0.0450277) |
0.232 |
0.105* |
66.59 |
47.32 |
| Diabetes | −0.0131651 (−0.034144 0.0078138) |
0.186 | |||
| CKD | −0.0716798 (−0.1465653 0.0032057) |
0.060 | |||
⁎
With Knapp-Hartung modification; BMI: body mass index; CKD: chronic kidney disease; CVD: cardiovascular damage; NOS: Newcastle Ottawa score; RAAS: renin-angiotensin-aldosterone system.