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. 2022 Nov 3;14:1027705. doi: 10.3389/fnagi.2022.1027705

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Copyright © 2022 Bai, Wan, Wang, Wu, Wang, Zhang, Xue, Xu and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Associations between retinal thickness, retinal vessel density, and AD-related proteins in AMD group. The AD-related biomarkers concentrations and MMSE scores were log-transformed. p < 0.05 was considered statistically significant. The blue area represented the 95% confidence interval. (A,B) The macular whole enface superficial vessel density values had a positive correlation with MMSE scores (r = 0.331, p = 0.045) but a negative correlation with the concentration of NfL (r = −0.464, p = 0.004). (C,D) The macular whole enface deep vessel density values were positively correlated with MMSE scores (r = 0.381, p = 0.020) and negatively correlated with the concentration of p-tau181 (r = −0.456, p = 0.031).