TABLE 1.

Average and standard deviations (in kcal/mol) of the binding energy of the RNA fragment GCCCUGG to the PCBP1 RNA-binding domain for the different oxidized guanine positions. The values are determined at different times along the 1-μs trajectories.

Time (μs)	Control	°GCCCUG°G	GCCCU°GG	°GCCCUGG	GCCCUG°G	°GCCC°GGG
0.5–0.6	−2.1 ± 8.9	−26.4 ± 8.4	−33.2 ± 11.9	−16.1 ± 7.3	−11.7 ± 8.1	0.4 ± 12.2
0.7–0.8	−12.8 ± 8.9	−24.8 ± 7.3	−19.3 ± 9.3	−8.1 ± 7.8	−10.5 ± 8.4	−3.9 ± 10.6
0.9–1	−13.3 ± 7.7	−25.5 ± 8.1	−19.6 ± 10.9	−10.0 ± 8.7	−3.3 ± 10.6	−7.2 ± 10.6