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. 2022 Nov 10;28(11):2321–2332. doi: 10.1038/s41591-022-02046-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a) Rare mutations at the DBH and TH genes are known to cause the IEMs orthostatic hypotension (OMIM #223360, coloured in orange) and Segawa syndrome (OMIM #605407, coloured in blue). b) In this study, we found common variants at these genes that are associated with metabolic and phenotypic consequences mimicking those observed in the corresponding IEMs.