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. 2022 Aug 25;28(11):2374–2380. doi: 10.1038/s41591-022-01977-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Kaplan–Meier curves of DOR in all patients. The median DOR and corresponding two-sided 95% CI were estimated by the Kaplan–Meier method. b, Forest plots of objective response in pre-specified subgroups. Odds ratios and corresponding two-sided 95% CIs were calculated using the Cochran–Mantel–Haenszel method. c, ORR in correlation with baseline PD-L1 levels. ORR and the corresponding two-sided 95% CI were calculated using the Clopper–Pearson method. d, Tumor response in correlation with baseline PD-L1 levels. Median percent change in tumor size over time was calculated descriptively (LOCF). Cemi, cemiplimab; chemo, chemotherapy; LOCF, last observation carried forward; met, metastasis; PBO, placebo.