Table 2.
Survival analyses across different age groups
| All ages A−T−: n = 781 A+T−: n = 292 A+TMTL+: n = 51 A+TNEO-T+: n = 60 |
50–69 years A−T−: n = 433 A+T−: n = 75 A+TMTL+: n = 12 A+TNEO-T+: n = 10 |
70–79 years A−T−: n = 256 A+T−: n = 123 A+TMTL+: n = 25 A+TNEO-T+: n = 29 |
80+ years A−T−: n = 92 A+T−: n = 94 A+TMTL+: n = 14 A+TNEO-T+: n = 21 |
|
|---|---|---|---|---|
| HR (95% CI), P | HR (95% CI), P | HR (95% CI), P | HR (95% CI), P | |
| Progression to MCI | ||||
| A+T− | 2.43 (1.38–4.26), P = 0.002 | 0.94 (0.25–3.59), P = 0.93 | 2.93 (1.16–7.39), P = 0.02 | 2.41 (0.90–6.42), P = 0.08 |
| A+TMTL+ | 14.60 (8.06–26.41), P < 0.001 | 17.19 (5.98–49.42), P < 0.001 | 21.94 (8.51–56.56), P < 0.001 | 5.14 (1.39–18.94), P = 0.01 |
| A+TNEO-T+ | 19.19 (10.93–33.71), P < 0.001 | 17.21 (4.54–65.19), P < 0.001 | 26.07 (10.79–62.99), P < 0.001 | 11.28 (3.91–32.57), P < 0.001 |
| Progression to all-cause dementia | ||||
| A+T− | 1.58 (0.46–5.41), P = 0.47 | 2.50 (0.27–23.00), P = 0.42 | 1.33 (0.16–10.84), P = 0.78 | 0.90 (0.50–15.98), P = 0.94 |
| A+TMTL+ | 6.22 (1.44–26.79), P = 0.01 | 18.09 (1.99–165), P = 0.01 | NA | 6.26 (0.34–116), P = 0.22 |
| A+TNEO-T+ | 41.26 (16.70–101.93), P < 0.001 | 28.17 (4.47–177), P < 0.001 | 47.62 (9.55–237), P < 0.001 | 27.69 (2.49–307.56), P = 0.007 |
The HR are derived from Cox proportional-hazards models with clinical progression (progression to MCI or all-cause dementia) as outcome, age, sex, education and cohort as covariates and A−T− serving as the reference group.
NA, there were no progressors to dementia in the A+TMTL+ group for this particular age bin.