Table 3.
Linear mixed models across different age groups
| All ages A−T−: n = 843 A+T−: n = 328 A+TMTL+: n = 55 A+TNEO-T+: n = 65 |
50–69 years A−T−: n = 442 A+T−: n = 77 A+TMTL+: n = 12 A+TNEO-T+: n = 10 |
70–79 years A−T−: n = 284 A+T−: n = 148 A+TMTL+: n = 27 A+TNEO-T+: n = 33 |
80+ years A−T−: n = 117 A+T−: n = 103 A+TMTL+: n = 16 A+TNEO-T+: n = 22 |
|
|---|---|---|---|---|
| Stdβ (s.e.), P | Stdβ (s.e.) P | Stdβ (s.e.) P | Stdβ (s.e.) P | |
| mPACC5 | ||||
| A+T− | −0.005 (0.001), P < 0.001 | −0.002 (0.001), P = 0.11 | −0.004 (0.001), P = 0.005 | −0.003 (0.003), P = 0.33 |
| A+TMTL+ | −0.017 (0.002), P < 0.001 | −0.015 (0.003), P < 0.001 | −0.016 (0.003), P < 0.001 | −0.015 (0.005), P = 0.004 |
| A+TNEO-T+ | −0.020 (0.002), P < 0.001 | −0.025 (0.004), P < 0.001 | −0.019 (0.003), P < 0.001 | −0.012 (0.005), P = 0.02 |
| MMSE | ||||
| A+T− | −0.008 (0.002), P < 0.001 | −0.001 (0.003), P = 0.73) | −0.007 (0.004), P = 0.06 | −0.013 (0.007), P = 0.06 |
| A+TMTL+ | −0.024 (0.005), P < 0.001 | −0.039 (0.008), P < 0.001) | −0.006 (0.008), P = 0.43 | −0.032 (0.014), P = 0.02 |
| A+TNEO-T+ | −0.056 (0.005), P < 0.001 | −0.050 (0.011), P < 0.001 | −0.049 (0.007), P < 0.001 | −0.063 (0.013), P < 0.001 |
The stdβ values are derived from the linear mixed models adjusted for age, sex, education and cohort and represent the group × time interaction with the A−T− serving as the reference group. P values from two-sided statistical tests without adjustment for multiple comparisons are reported.