Extended Data Table 5.

Linear mixed models for the full A^-T^- sample versus an age-matched A^-T^- sample. In this analysis, the A^-T^- sample was restricted to individuals older than 65 years (n = 541), so that there was no longer any significant age difference between the AT groups. The standardized beta values are derived from the linear mixed models adjusted for age, sex, education and cohort, and represent the group × time interaction with the A⁻T⁻ serving as the reference group. P values from two-sided statistical tests without adjustment for multiple comparisons are reported