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. 2022 Sep 22;28(11):2309–2320. doi: 10.1038/s41591-022-01980-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Displayed are distributions for all measured metabolites (n = 168) stratified by the region (A, B, and C) in the attribution space, defined by the UMAP of the attributions for T2D (see Extended Data Figure 9c). Regions were defined by including all samples with an euclidean distance < 1 to the centroid A, B, and C, respectively; a Euclidean distance of 1 is indicated by the scale bar (see Extended Data Figure 9c). The distributions differ notably for metabolites, including glucose, fatty acids (that is LA and Omega-6), and multiple lipoprotein components (that is VLDL cholesterol and very large HDL triglycerides).