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. 2022 Sep 22;28(11):2309–2320. doi: 10.1038/s41591-022-01980-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Observed event frequency for incident disease plotted against metabolomic state percentiles over the entire study population for all 24 endpoints. b, Cumulative event rates over the observation time for all assessed endpoints, stratified by metabolomic state quantiles (light blue, bottom 10%; blue, median 10%; dark blue, top 10%), with 95% CIs indicated. PAD, peripheral artery disease.