Table 1.

Participant Composition by Sleep Disturbance.

‘Variables	Overall		Sleep Disturbance – Present		Sleep Distuirbance – Absent		p value
	n = 1533		n = 209		n = 1324
	N	%	N	%	N	%
Sex							0.008
Male	649	42.34	106	16.33	543	83.67
Female	884	57.66	103	11.65	781	88.35
Race a							0.553
Black	183	11.98	25	13.66	158	86.34
Other	57	3.73	5	8.77	52	91.23
White	1288	84.29	178	13.82	1110	84.18
Hispanic b							<0.001
Yes	140	10.83	33	23.57	107	76.43
No	1384	89.17	174	12.57	1210	87.43
e4 carrier							0.260
Yes	642	41.88	95	14.8	547	85.2
No	891	58.12	114	12.79	777	87.21
	Mean	SD	Mean	SD	Mean	SD	p value	Adjusted p valued
Age	71.88	10.30	73.11	9.44	71.69	10.41	0.063	N/A
Education c	15.01	3.55	14.25	3.96	15.13	3.47	0.003	N/A
Total intracranial volume	1363.87	142.44	1357.60	151.90	1364.90	140.90	0.497	0.513
Total white matter volume	450.73	60.54	448.40	63.75	451.10	60.04	0.551	0.551
Total brain volume	1015.06	114.37	999.20	117.60	1017.60	113.70	0.031	0.048
Total brain cerebrospinal fluid volume	340.66	63.35	347.30	66.84	339.60	62.74	0.102	0.132
Total brain gray matter volume	572.49	62.62	561.90	64.06	574.20	62.26	0.009	0.019
Total brain white matter volume	442.57	62.28	437.30	64.88	443.40	61.85	0.185	0.212
Total brain white matter hyperintensity volume	8.15	11.79	11.15	14.64	7.68	11.21	<0.001	<0.001
Total cerebrum cranial volume	1175.64	128.46	1169.90	135.20	1176.50	127.40	0.489	0.513
Total cerebrum brain volume	888.34	101.82	876.00	104.70	890.30	101.30	0.059	0.088
Total cerebrum cerebrospinal fluid volume	287.30	55.65	293.90	59.49	286.30	54.97	0.064	0.090
Total cerebrum gray matter volume	475.61	57.86	465.40	58.01	477.20	57.70	0.006	0.014
Total cerebrum white matter volume	404.60	57.26	399.50	60.25	405.40	56.76	0.167	0.199
Left hippocampus volume	3.01	0.48	2.91	0.47	3.02	0.48	0.003	0.011
Right hippocampus volume	3.07	0.47	3.00	0.48	3.08	0.47	0.017	0.028
Hippocampal volume	6.08	0.92	5.91	0.92	6.11	0.92	0.005	0.014
Left lateral ventricle volume	18.86	11.75	21.73	13.24	18.41	11.44	<0.001	0.002
Right lateral ventricle volume	17.49	11.15	19.89	12.12	17.11	10.95	0.001	0.005
Total lateral ventricle volume	36.35	22.40	41.62	24.76	35.52	21.90	<0.001	0.003
Total third ventricle volume	1.38	0.58	1.51	0.59	1.36	0.58	0.001	0.004
Left frontal lobe cortical gray matter volume	82.62	11.85	80.42	11.46	82.97	11.88	0.004	0.012
Right frontal lobe cortical gray matter volume	82.87	11.00	80.79	11.03	83.20	10.96	0.003	0.011
Total frontal lobe cortical gray matter volume	166.11	22.78	161.80	22.34	166.80	22.78	0.003	0.011
Left occipital lobe cortical gray matter volume	28.74	4.54	28.37	4.81	28.80	4.50	0.204	0.225
Right occipital lobe cortical gray matter volume	29.33	4.72	28.82	4.59	29.41	4.74	0.094	0.126
Total occipital lobe cortical gray matter volume	58.18	8.84	57.30	8.93	58.32	8.82	0.123	0.152
Left parietal lobe cortical gray matter volume	45.80	6.17	44.85	6.18	45.95	6.16	0.017	0.028
Right parietal lobe cortical gray matter volume	46.36	6.27	45.39	6.48	46.51	6.22	0.016	0.028
Total parietal lobe cortical gray matter volume	92.25	12.13	90.34	12.41	92.55	12.06	0.014	0.028
Left temporal lobe cortical gray matter volume	58.64	7.18	57.21	7.84	58.87	7.05	0.002	0.010
Right temporal lobe cortical gray matter volume	56.20	6.94	55.13	7.32	56.37	6.87	0.017	0.028
Total temporal lobe cortical gray matter volume	115.09	13.83	112.60	14.85	115.50	13.63	0.005	0.014

^a5 missing cases,

^b9 missing cases,

^c8 missing cases,

^dp values adjusted by FDR.