Table 3.
Adjusted Effect of Sleep Disturbance.
| MRI volumetric variables | Sleep Disturbance (Yes vs No) | ||||
|---|---|---|---|---|---|
| B | SE | 95 % CI | p value | FDR corrected p value | |
| Total white matter volume | −0.526 | 2.541 | (−5.511,4.460) | 0.836 | 0.865 |
| Total brain volume | −10.241 | 2.888 | (−15.906,−4.575) | <0.001 | <0.001 |
| Total brain cerebrospinal fluid volume | 7.332 | 2.770 | (1.898,12.766) | 0.008 | 0.016 |
| Total brain gray matter volume | −6.806 | 1.996 | (−10.722,−2.891) | 0.001 | 0.005 |
| Total brain white matter volume | −3.434 | 2.579 | (−8.494,1.625) | 0.183 | 0.220 |
| Total brain white matter hyperintensity volume | 2.909 | 0.809 | (1.322,4.496) | <0.001 | <0.001 |
| Total cerebrum cranial volume | −0.155 | 1.234 | (−2.575,2.265) | 0.900 | 0.900 |
| Total cerebrum brain volume | −7.318 | 2.634 | (−12.484,−2.151) | 0.006 | 0.013 |
| Total cerebrum cerebrospinal fluid volume | 7.163 | 2.462 | (2.333,11.992) | 0.004 | 0.009 |
| Total cerebrum gray matter volume | −6.266 | 2.019 | (−10.226,−2.306) | 0.002 | 0.006 |
| Total cerebrum white matter volume | −3.956 | 2.484 | (−8.829,0.917) | 0.112 | 0.140 |
| Left hippocampus volume | −0.075 | 0.030 | (−0.134,−0.016) | 0.013 | 0.023 |
| Right hippocampus volume | −0.055 | 0.030 | (−0.113,0.003) | 0.064 | 0.087 |
| Hippocampal volume | −0.129 | 0.057 | (−0.240,−0.018) | 0.022 | 0.035 |
| Left lateral ventricle volume | 2.743 | 0.730 | (1.310,4.175) | <0.001 | <0.001 |
| Right lateral ventricle volume | 2.218 | 0.703 | (0.838,3.598) | 0.002 | 0.006 |
| Total lateral ventricle volume | 4.962 | 1.387 | (2.242,7.681) | <0.001 | <0.001 |
| Total third ventricle volume | 0.107 | 0.034 | (0.041,0.173) | 0.002 | 0.006 |
| Left frontal lobe cortical gray matter volume | −1.256 | 0.478 | (−2.193,−0.318) | 0.009 | 0.017 |
| Right frontal lobe cortical gray matter volume | −1.324 | 0.433 | (−2.173,−0.475) | 0.002 | 0.006 |
| Total frontal lobe cortical gray matter volume | −2.588 | 0.884 | (−4.323,−0.854) | 0.004 | 0.009 |
| Left occipital lobe cortical gray matter volume | −0.258 | 0.255 | (−0.758,0.241) | 0.311 | 0.333 |
| Right occipital lobe cortical gray matter volume | −0.317 | 0.256 | (−0.820,0.185) | 0.215 | 0.241 |
| Total occipital lobe cortical gray matter volume | −0.578 | 0.468 | (−1.495,0.340) | 0.217 | 0.241 |
| Left parietal lobe cortical gray matter volume | −0.552 | 0.284 | (−1.110,0.005) | 0.052 | 0.074 |
| Right parietal lobe cortical gray matter volume | −0.541 | 0.296 | (−1.121,0.039) | 0.067 | 0.087 |
| Total parietal lobe cortical gray matter volume | −1.083 | 0.539 | (−2.140,−0.027) | 0.045 | 0.068 |
| Left temporal lobe cortical gray matter volume | −1.160 | 0.353 | (−1.853,−0.466) | 0.001 | 0.005 |
| Right temporal lobe cortical gray matter volume | −0.817 | 0.348 | (−1.499,−0.135) | 0.019 | 0.032 |
| Total temporal lobe cortical gray matter volume | −1.974 | 0.661 | (−3.272, −0.677) | 0.003 | 0.008 |
n = 1512; adjusted by intracranial volume, sex, age, education, race, Hispanic ethnicity. All volumes measured in cubic centimeters (cc).