Table 4.
Moderation Effect of APOE ε 4.
| MRI volumetric variables | Sleep Disturbance*APOE ε 4 | ||||
|---|---|---|---|---|---|
| B | SE | 95 % CI | p value | FDR corrected p value | |
| Total white matter volume | 4.522 | 5.067 | (−5.418,14.462) | 0.372 | 0.665 |
| Total brain volume | −3.794 | 5.758 | (−15.088,7.500) | 0.510 | 0.665 |
| Total brain cerebrospinal fluid volume | 2.675 | 5.523 | (−8.159,13.509) | 0.628 | 0.725 |
| Total brain gray matter volume | −7.197 | 3.973 | (−14.991,0.597) | 0.070 | 0.525 |
| Total brain white matter volume | 3.403 | 5.144 | (−6.687,13.492) | 0.508 | 0.665 |
| Total brain white matter hyperintensity volume | 1.119 | 1.613 | (−2.046,4.284) | 0.488 | 0.665 |
| Total cerebrum cranial volume | 2.704 | 2.456 | (−2.113,7.522) | 0.271 | 0.665 |
| Total cerebrum brain volume | 0.054 | 5.246 | (−10.236,10.344) | 0.992 | 0.992 |
| Total cerebrum cerebrospinal fluid volume | 2.651 | 4.908 | (−6.977,12.279) | 0.589 | 0.707 |
| Total cerebrum gray matter volume | −5.631 | 4.013 | (−13.504,2.241) | 0.161 | 0.665 |
| Total cerebrum white matter volume | 4.616 | 4.954 | (−5.100,14.333) | 0.352 | 0.665 |
| Left hippocampus volume | 0.045 | 0.060 | (−0.072,0.162) | 0.448 | 0.665 |
| Right hippocampus volume | 0.069 | 0.058 | (−0.046,0.183) | 0.240 | 0.665 |
| Hippocampal volume | 0.114 | 0.112 | (−0.106,0.333) | 0.309 | 0.665 |
| Left lateral ventricle volume | −0.552 | 1.455 | (−3.405,2.302) | 0.705 | 0.755 |
| Right lateral ventricle volume | −1.650 | 1.401 | (−4.399,1.099) | 0.239 | 0.665 |
| Total lateral ventricle volume | −2.199 | 2.763 | (−7.618,3.220) | 0.426 | 0.665 |
| Total third ventricle volume | 0.054 | 0.067 | (−0.078,0.186) | 0.422 | 0.665 |
| Left frontal lobe cortical gray matter volume | −0.732 | 0.952 | (−2.599,1.136) | 0.442 | 0.665 |
| Right frontal lobe cortical gray matter volume | 0.137 | 0.861 | (−1.553,1.826) | 0.874 | 0.904 |
| Total frontal lobe cortical gray matter volume | −0.694 | 1.760 | (−4.145,2.758) | 0.694 | 0.755 |
| Left occipital lobe cortical gray matter volume | −0.621 | 0.507 | (−1.616,0.375) | 0.221 | 0.665 |
| Right occipital lobe cortical gray matter volume | −0.410 | 0.510 | (−1.411,0.591) | 0.422 | 0.665 |
| Total occipital lobe cortical gray matter volume | −1.046 | 0.932 | (−2.874,0.781) | 0.262 | 0.665 |
| Left parietal lobe cortical gray matter volume | −1.358 | 0.566 | (−2.468,−0.248) | 0.017 | 0.170 |
| Right parietal lobe cortical gray matter volume | −1.401 | 0.588 | (−2.555,−0.247) | 0.017 | 0.170 |
| Total parietal lobe cortical gray matter volume | −2.762 | 1.072 | (−4.865,−0.660) | 0.010 | 0.170 |
| Left temporal lobe cortical gray matter volume | −0.961 | 0.703 | (−2.340,0.418) | 0.172 | 0.665 |
| Right temporal lobe cortical gray matter volume | −0.420 | 0.691 | (−1.775,0.934) | 0.543 | 0.679 |
| Total temporal lobe cortical gray matter volume | −1.427 | 1.314 | (−4.004,1.151) | 0.278 | 0.665 |
n = 1512, adjusted by intracranial volume, sex, age, education, race, and Hispanic ethnicity. All volumes measured in cubic centimeters (cc).