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. Author manuscript; available in PMC: 2023 Nov 16.
Published in final edited form as: Neuron. 2022 Oct 6;110(22):3820–3832.e4. doi: 10.1016/j.neuron.2022.09.011

Figure 2.

Figure 2.

Habenula tract and its topological feature with the control tracts within and posterior to the anterior limb of the internal capsule (ALIC) in one representative subject. (A) Designation of subsections using anatomical landmarks with habenula tracts (green) overlaid: S1, anterior of the habenula to anterior thalamus; S2, anterior of the thalamus to anterior caudate; S3, anterior of the caudate to PFC grey matter. (B) Topology of the habenula tracts (blue) immediately posterior to (upper panel) and within (lower panel) the ALIC (S2) compared to control AT (yellow) and VTA (red) tracts. The habenula tracts display a ventral-medial trajectory relative to the control tracts that is maintained throughout the ALIC. (C) Percentage of voxels shared between masks of each tract in CUD subjects and their matched CTL group within S2 (e.g., Hb-AT denotes the percentage of Hb tract voxels that are also contained within the AT tract, see main text for detail). Boxplot represents the median (center line), interquartile range (box), and 1.5x the interquartile range (whiskers).