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. Author manuscript; available in PMC: 2023 Nov 16.
Published in final edited form as: Neuron. 2022 Oct 6;110(22):3820–3832.e4. doi: 10.1016/j.neuron.2022.09.011

Figure 3.

Figure 3.

Distinct PFC-Hb streamline terminal distributions as compared to those from control seed regions. (A) Tracts seeded in subcortical seeds, the habenula (Hb, blue), anterior thalamus (AT, yellow), and ventral tegmental area (VTA, red), with streamline terminals in the PFC from a representative subject. (B) Comparison of the distribution of streamline terminals in the PFC for tracts seeded in subcortical seeds, averaged between left and right sides. (C) CUD vs. CTL group comparisons of the distribution of streamline terminals from each of the subcortical seeds. *p < .05, **p < .01, ***p < .001. SFG = superior frontal gyrus; MFG = middle frontal gyrus; IFG = inferior frontal gyrus; OFC = orbitofrontal cortex; FP = frontal pole; ACC = anterior cingulate cortex; CTL = control individuals; CUD+ = currently using cocaine-addicted individuals; CUD− = short-term abstinent cocaine-addicted individuals. Boxplots represent the median (center line), interquartile range (box), and 1.5x the interquartile range (whiskers).