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a Extrachromosomal DNA (ecDNA) contains more accessible chromatin compared to linear chromosomal DNA, reflected by the increased read density and number of peaks in assay for transposase-accessible chromatin sequencing (ATAC-seq) profiles. b | The re-arrangement of distal chromosomal fragments into ecDNAs results in three-dimensional reorientation of chromatin elements and enables the ‘hijacking’ of distal enhancers.
