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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Nat Rev Genet. 2022 Aug 11;23(12):760–771. doi: 10.1038/s41576-022-00521-5

Figure 6. Opportunities for development of ecDNA targeting therapeutic strategies.

Figure 6.

New therapeutic approaches may be designed to target the amplification vehicle rather than amplified cargo genes, for improved outcomes of patients with extrachromosomal DNA (ecDNA)-containing cancer. At least five potential strategies for therapy are under consideration, including: blocking ecDNA replication (1); perturbing ecDNA segregation (2); disrupting ecDNA clustering into hubs (3); preventing new ecDNA formation (4); and promoting ecDNA expulsion in micronuclei (5).