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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Osteoarthritis Cartilage. 2022 Sep 6;30(12):1616–1630. doi: 10.1016/j.joca.2022.08.015

Figure 1. Protein levels of CCR2 and GFP in the AC of CCR2-AggKO and CCR2+/+ mice following Tam injections.

Figure 1.

(A) Paraffin embedded knee joint sections are immunostained for CCR2 and GFP, two weeks after the first Tam injection. Positive staining is detected as brown precipitate (red arrows). CCR2 staining is detected in the AC of CCR2+/+ mice, while is absent in CCR2-AggKO. Conversely, GFP staining is visible in CCR2-AggKO (red arrows) but undetected in CCR2+/+ mice. (B) Images represent a magnification of the rectangle in the articular cartilage defined in panel A. (C) Images represent a magnification of the rectangle in the meniscus defined in panel A. Images are representative of 6 different mice for each of the experimental groups described, ranging between 14 and 18 weeks of age. Scale bars are 100 μm.