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. 2022 Nov 17;12:19740. doi: 10.1038/s41598-022-22465-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Baseline cross-disease correlation between disease activity and pathway activities. (a) Psoriasis related pathways are positively correlated with Mayo Scores of UC patients (lesional colon at baseline); Y axis indicates # of pathways/gene sets; X axis is correlation coefficient between pathway/gene set activity and UC disease activity as represented as Mayo Score. (b) Pathways dysregulated in UC related are positively correlated with disease scores (PASI) of psoriasis patients (lesional skin at baseline); Y axis indicates # of pathways/gene sets; X axis is correlation coefficient between pathway/gene set activity and psoriasis disease activity as represented as PASI.