Table 1.
DEGs in the shared signature in IL-17 signaling pathway.
| IL17 signaling | ||||
|---|---|---|---|---|
| Symbol | Entrez gene name | Expr log ratio | Expr p-value | Expr q-value |
| UCTR | ||||
| CCL11 | C–C motif chemokine ligand 11 | 1.202 | 3.31E−08 | 1.19E−07 |
| CCL2 | C–C motif chemokine ligand 2 | 1.683 | 9.95E−24 | 3.17E−22 |
| CCL20 | C–C motif chemokine ligand 20 | 1.613 | 9.24E−13 | 5.72E−12 |
| CCL22 | C–C motif chemokine ligand 22 | 1.906 | 3.89E−15 | 3.25E−14 |
| CD70 | CD70 molecule | 2.096 | 8.64E−27 | 5.08E−25 |
| CEBPB | CCAAT enhancer binding protein beta | 1.176 | 3.11E−20 | 5.41E−19 |
| CLCF1 | Cardiotrophin like cytokine factor 1 | 1.183 | 1.37E−16 | 4.56E−26 |
| CXCL1 | C-X-C motif chemokine ligand 1 | 3.95 | 4.65E−45 | 3.35E−41 |
| CXCL3 | C-X-C motif chemokine ligand 3 | 3.105 | 7.67E−34 | 3.76E−36 |
| DEFB1 | Defensin beta 1 | − 1.696 | 2.16E−15 | 1.87E−14 |
| EDA | Ectodysplasin A | − 1.825 | 2.33E−05 | 1.54E−23 |
| FOS | Fos proto-oncogene, AP-1 transcription factor subunit | 1.748 | 5.36E−14 | 3.93E−13 |
| IL11 | Interleukin 11 | 3.059 | 2.12E−16 | 2.13E−15 |
| IL33 | Interleukin 33 | 1.741 | 7.31E−25 | 3.42E−24 |
| IL1A | Interleukin 1 alpha | 3.607 | 1.84E−25 | 8.22E−24 |
| IL1B | Interleukin 1 beta | 3.264 | 6.48E−24 | 2.18E−22 |
| LCN2 | Lipocalin 2 | 3.316 | 2.94E−26 | 1.54E−24 |
| LTA | Lymphotoxin alpha | 1.566 | 8.59E−17 | 9.16E−16 |
| LTB | Lymphotoxin beta | 1.45 | 2.68E−15 | 2.29E−14 |
| MAPK11 | Mitogen-activated protein kinase 11 | 1.5 | 1.65E−31 | 3.13E−29 |
| MMP2 | Matrix metallopeptidase 2 | 1.056 | 9.15E−09 | 5.53E−10 |
| MMP3 | Matrix metallopeptidase 3 | 4.764 | 4.15E−24 | 1.46E−22 |
| MMP9 | Matrix metallopeptidase 9 | 2.129 | 5.06E−10 | 5.32E−19 |
| MRAS | Muscle RAS oncogene homolog | 1.167 | 1.95E−22 | 9.68E−23 |
| MUC5AC | Mucin 5AC, oligomeric mucusgel-forming | 4.087 | 2.1E−16 | 1.32E−16 |
| NOS2 | Nitric oxide synthase 2 | 2.714 | 3.03E−10 | 3.87E−22 |
| OSM | Oncostatin M | 3.476 | 1.32E−17 | 1.57E−16 |
| PGF | Placental growth factor | 1.38 | 6.05E−21 | 1.19E−19 |
| PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | 1.042 | 4.57E−14 | 3.38E−13 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 2.476 | 6.59E−17 | 7.14E−16 |
| RGS16 | Regulator of G protein signaling 16 | 1.856 | 5.13E−26 | 2.54E−24 |
| TGFB2 | Transforming growth factor beta 2 | 1.591 | 6.29E−21 | 1.24E−19 |
| TGFB3 | Transforming growth factor beta 3 | 1.336 | 4.34E−10 | 1.54E−16 |
| TNF | Tumor necrosis factor | 1.158 | 2.58E−13 | 1.72E−12 |
| TNFRSF11B | TNF receptor superfamily member 11b | 1.11 | 1.24E−11 | 6.62E−11 |
| TNFSF8 | TNF superfamily member 8 | 1.4 | 1.9E−20 | 3.44E−19 |
| TNFSF9 | TNF superfamily member 9 | 2.462 | 3.63E−30 | 4.63E−28 |
| TNFSF11 | TNF superfamily member 11 | 1.883 | 8.88E−14 | 6.31E−13 |
| TNFSF13B | TNF superfamily member 13b | 1.098 | 2.43E−17 | 2.8E−16 |
| VEGFC | Vascular endothelial growth factor C | 1.632 | 1.01E−35 | 6.63E−33 |
| PSTR | ||||
| CDC25A | Cell division cycle 25A | 1.057 | 2.54E−03 | 2.55E−24 |
| IL7R | Interleukin 7 receptor | 1.188 | 2.78E−04 | 5.18E−23 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 1.182 | 2.40E−44 | 1.60E−52 |
| SHC1 | SHC adaptor protein 1 | 1.203 | 3.99E−12 | 8.00E−38 |
| SLC2A1 | Solute carrier family 2 member 1 | 1.242 | 2.63E−34 | 6.02E−33 |
| STAT1 | Signal transducer and activator of transcription 1 | 1.882 | 3.29E−03 | 1.93E−56 |
Expr Log Ratio: log2 FC between lesional and nonlesional samples in PS or UC.
DEG differentially expressed gene, PSTR psoriasis transcriptome, UCTR ulcerative colitis transcriptome.