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. 2022 Nov 17;13:7038. doi: 10.1038/s41467-022-34808-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Western blotting assay (a) and IHC staining (b) reveal the effect of reconstitution of GYS2. Luc, Luciferase. For figure b, bar = 50 μm. n = 5 animals. Data are presented as mean values +/− SEM. One-way ANOVA was performed to determine a difference between columns. ***p < 0.001. c–e Hepatic glycogen content assay (c) PAS staining (d) and transmission electron microscope pictures (e) of mouse livers with indicated genotypes and a luciferase (Luc) or Gys2-overexpressing adeno-associated virus (AAV). Bar: 50 μm (d), 0.5 μm (e). n ≥ 4 animals. Data are presented as mean values +/− SEM. One-way ANOVA was performed to determine a difference between columns in figure (c) and (d). ***p < 0.001. f Serum glucose level of indicated groups of mice in free diet. n ≥ 4 animals. Data are presented as mean values +/− SEM. One-way ANOVA was performed to determine a difference between columns. *p < 0.05; **p < 0.01. g Blood glucose level of indicated groups of mice after prolonged fasting. n ≥ 4 animals. Data are presented as mean values +/− SEM. One-way ANOVA was performed to determine a difference between columns. *p < 0.05; ***p < 0.001. h Exhaustive swimming assay of indicated groups of mice. n ≥ 6 animals. Data are presented as mean values +/− SEM. One-way ANOVA was performed to determine a difference between columns. ***p < 0.001. Source data are provided as a Source data file.