Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 17;13:7028. doi: 10.1038/s41467-022-34801-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Representative images showing live GAC signal detected by an IVIS Lumina II system in Glb1^m/m, Glb1^+/m, and Glb1^+/+ mice at 12 months of age. b Representative images showing live GAC signal in indicated organs isolated from 3-month-old Glb1^+/+ and Glb1^+/m mice and 19-month-old Glb1^+/m mice. c Representative live GAC signal images of a cohort of Glb1^+/m mice (n = 60) at indicated ages. A Glb1^+/+ mouse was included as a background control. d A cohort of Glb1^+/m mice (n = 60) at 9, 11, 13, 15, and 17 months of age were live-imaged, and linear regression between GAC signal and chronological age was analyzed. There was a close correlation between GAC signal and chronological age for months 9, 11, and 13. X-axis, month-groups of mice; Y-axis, numbers of month-groups involved for analysis; Z-axis, R² of linear regression; Error bar, MSE of linear regression. e Plot showing linear correlation between GAC signal and chronological age in middle-aged mice (MA, 9 to 13 months, n = 27). A 85% confidence interval was applied to define mice with GAC high signal (GACH) and mice with low GAC signal (GACL). Data represent the means ± s.e.m. f Comparison of lifespan between middle-aged mice with high (n = 5) and low (n = 14) GAC signal by the Log-rank (Mantel–Cox) test. “n” represents number of biological replicates.