Fig. 8. Lapatinib response is defined by phenotypically-distinct stable and interconverting states.

a State transition graph showing the probability of state transitions among the predicted states. Transitions with less than a 0.03 probability have been removed. b–e A sample of lineage trees after fitting the model and state assignment (control, 25 nM, 50 nM, and 250 nM). f–g The log₁₀ of fit mean time of G1 and S/G2 phase durations for different concentrations. h, i The Bernoulli parameter, indicating the probability of G1-to-S phase transition versus cell death (h), and the probability of division versus cell death (i) for each concentration.