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. 2022 Aug 2;37(3):629–637. doi: 10.1007/s12028-022-01561-9

Table 2.

Results of univariate and multivariable analyses

Univariate Multivariable
OR 95% CI p OR 95% CI p
Patient-associated factors
Age 1.02 0.998–1.04 0.085 1.00 0.97–1.02 0.83
Female sex 2.84 1.13–7.15 0.027 2.45 0.86–6.99 0.095
Major comorbidity 2.57 1.31–5.04 0.006 2.24 0.93–5.38 0.072
 Cardiovascular 3.12 1.56–6.25 0.001
 Diabetes 4.56 1.69–12.32 0.003
 Pulmonary 0.82 0.29–2.29 0.702
Antithrombotic agents 3.33 1.34–8.27 0.010 1.94 0.61–6.17 0.264
 Anticoagulant agents 2.17 0.75–6.34 0.160
 Antiplatelet agents 5.31 1.09–25.95 0.039
SSRI or SNRI medication 2.08 0.48–9.04 0.330
Chronic alcohol misuse 0.91 0.46–1.81 0.790 1.41 0.63–3.15 0.404
Previous TBI 1.00 0.40–2.48 0.995
 Trauma-associated factors
Primary GCS score 0.94 0.85–1.03 0.188
Primary CT findings
 Intra-axial trauma lesions 1.54 0.79–3.01 0.204
 Midline shift 2.03 1.03–4.01 0.042 2.26 1.05–4.84 0.036
Extracranial injuries 3.14 1.31–7.54 0.010 4.71 1.74–12.73 0.002
Treatment-associated factors
Major neurosurgical intervention 5.69 2.75–11.78  < 0.001

CI confidence interval, CT computed tomography, GCS Glasgow Coma Scale, OR odds ratio, SNRI serotonin and noradrenalin reuptake inhibitor, SSRI selective serotonin reuptake inhibitor, TBI traumatic brain injury