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. 2022 Nov 17;79(12):596. doi: 10.1007/s00018-022-04565-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — CPI-455 reduced CP-induced HC loss in ex vivo cochlear explants. A–C Cochlear explants were stained for Myosin 7a (red) and DAPI (blue). Scale bar 10 μm. D–F Graphical representation of the number of Myosin 7a–positive HCs per each treatment. The data are presented as the mean ± SEM values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the control; ^##P < 0.01, ^###P < 0.001, ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. n = 6 cochleae for control group; n = 6 cochleae for CP group; n = 6 cochleae for 50 μmol/L CPI-455 + CP group; n = 6 cochleae for 100 μmol/L CPI-455 + CP group; n = 6 cochleae for 200 μmol/L CPI-455 + CP group; n = 6 cochleae for 100 μmol/L CPI-455 group