Fig. 2.

CPI-455 reduced CP-induced HC apoptosis. A–C Cochlear explants were stained with Myosin 7a (green), TUNEL (red), and DAPI (blue). Images were captured from the cochlea's apex, middle, and base turns per condition. Scale bar 10 μm. D Statistical plot of Myosin 7a/TUNEL-positive cells in A–C. The data are presented as the mean ± SEM. ****P < 0.0001 compared with the control and ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. n = 8 cochleae for control group; n = 8 cochleae for CP group; n = 8 cochleae for CPI-455 + CP group; n = 8 cochleae for CPI-455 group