Fig. 3.

CPI-455 reduced CP-induced ROS generation in cochlear HCs. A–C Cochlear explants were stained with Myosin 7a (green), MitoSOX™ red (red), and DAPI (blue). Images were captured from the cochlea's apex, middle, and base turns per condition. Scale bar 10 μm. D Comparison of MitoSOX™ red signals between each group. The data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. n = 9 cochleae for control group; n = 9 cochleae for CP group; n = 9 cochleae for CPI-455 + CP group; n = 9 cochleae for CPI-455 group