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. 2022 Nov 17;79(12):596. doi: 10.1007/s00018-022-04565-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — CPI-455 protected mice from CP-induced synapses loss. A–C Cochleae were stained for CtBP2 (magenta) and GluR2 (green). Scale bar 10 μm. D, E Quantification of CtBP2-immunolabeled or GluR2-immunolabeled synaptic ribbons per IHCs. The data are presented as the mean ± SEM values. *P < 0.05, ***P < 0.001, ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. n = 6 cochleae for control group; n = 6 cochleae for CP group; n = 6 cochleae for CPI-455 + CP group; n = 6 cochleae for CPI-455 group. F ABR wave I amplitudes analysis. Data are shown as mean ± SEM values. ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. n = 6 mice for each group