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. 2022 Nov 17;79(12):596. doi: 10.1007/s00018-022-04565-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — CPI-455 affected KDM5A and H3K4me3 expression in cochlear HCs. A, B The protein levels of KDM5A, KDM5B, KDM5C, and H3K4me3. GAPDH served as an internal control. Data are presented as mean ± SEM values. *P < 0.05, ***P < 0.001, ****P < 0.0001 compared with the control; ^###P < 0.001, ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. C Cochleae were stained for KDM5A (red) and Myosin 7a (green). D Cochleae were stained for H3K4me3 (red) and parvalbumin (green). Images were captured from the middle turns of the cochlea. Scale bars 10 μm