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. 2022 Nov 17;79(12):596. doi: 10.1007/s00018-022-04565-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Downregulation of KDM5A reduced CP-induced apoptosis in HEI-OC1 cells. A–C Effects of KDM5A on early (Annexin V-FITC positive, PI negative) and late (Annexin V-FITC/PI double positive) cell apoptosis were (A) determined via flow cytometry and (B, C) quantified. The data are presented as three independent experiments' mean ± SEM values. ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. D–F Representative images and histogram analysis of CellROX™ green in HEI-OC1 cells. Scale bar = 10 μm. The data are presented as three independent experiments' mean ± SEM values. ***P < 0.001, ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. G–I Representative images and histogram analysis of Rhodamine 123 in HEI-OC1 cells. Scale bar 10 μm. The data are presented as three independent experiments' mean ± SEM values. ****P < 0.0001 compared with the control; ^###P < 0.001 compared with CP only. J–N OCRs and bioenergetics parameters in HEI-OC1 cells from each group. The data are presented as mean ± SEM values. **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the control; ^##P < 0.01, ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate