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. 2022 Nov 17;79(12):596. doi: 10.1007/s00018-022-04565-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — CPI-455 reduced CP-induced HC death via multiple signaling pathways. A Volcano plot representing gene-expression differences between CPI-455 + CP and CP. B KEGG analysis showed the distribution of terms exhibiting statistically significant differences. C The differentially expressed genes were verified in HEI-OC1 cells by qRT-PCR. Data are presented as mean ± SEM values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the control; ^##P < 0.01, ^####P < 0.0001 compared with CP only. D–F Enrichment of H3K4me3 on promoters of Sos1, Sos2, and Map3k3 genes. Data were normalized to the IgG controls. Data are presented as mean ± SEM values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with the control; ^###P < 0.001, ^####P < 0.0001 compared with CP only. G, H The protein levels of p-P38, P38, p-JNK, JNK, p-AKT, AKT, p-PI3K, PI3K, C-Casp3, C3, BAX, and Bcl-2 in HEI-OC1 cells. GAPDH serves as an internal control. Data are presented as mean ± SEM values. ***P < 0.001, ****P < 0.0001 compared with the control; ^####P < 0.0001 compared with CP only. The experiments were performed in triplicate. I Summary of the working thesis of the study