TABLE 3.

Arrhythmia Signal Profiles of Different ICI Strategies.

IC025>0	Ipilimumab	Tremelimumab	Nivolumab	Pembrolizumab	Cemiplimab	Atezolizumab	Avelumab	Durvalumab	Ipilimumab + Nivolumab	Tremelimumab + Durvalumab
Atrioventricular block complete	—	—	1.17	2.00	—	0.73	—	0.29	1.09	—
Bundle branch block right	—	—	−1.57	−1.67	—	—	—	—	−0.02	—
Atrioventricular block	—	—	0.50	0.18	—	−1.49	—	—	0.90	—
Bundle branch block left	—	—	—	−1.16	—	−0.63	—	—	−0.89	—
Arrhythmia	—	—	−0.33	−0.75	−1.03	−2.47	—	−2.70	−1.58	—
Bradycardia	—	—	−1.46	−1.70	—	−1.95	0.51	−2.96	−3.06	—
Tachycardia	−2.18	0.48	−0.89	−0.45	—	−0.83	−1.15	−0.58	−0.61	—
Atrial fibrillation	−0.66	—	0.19	0.12	—	0.80	−0.51	0.36	0.78	−2.80
Sinus tachycardia	—	—	−0.26	−0.61	—	0.14	—	−1.66	1.76	—
Atrial flutter	—	—	0.62	−0.44	—	0.53	—	—	0.24	1.35
Sinus node dysfunction	—	—	0.71	−1.84	—	−0.90	—	—	—	—
Supraventricular tachycardia	—	—	0.43	0.43	—	1.36	—	−1.17	0.42	—
Cardiac arrest	−1.38	—	−0.35	−1.03	—	−0.95	0.20	−0.49	0.01	0.47
Sudden death	—	—	1.34	1.34	—	1.08	1.17	−1.21	1.90	0.45
Ventricular tachycardia	—	—	−0.90	0.59	—	—	—	—	−0.61	—
Cardio-respiratory arrest	—	—	−0.54	−0.87	—	−1.00	—	−0.74	−1.59	—
Ventricular fibrillation	—	—	−1.32	−0.90	—	—	—	—	—	—