Table 4.
Summary of significant predictors of specific distant metastases at the time of diagnosis based on univariate and multivariable logistic regression hazard analysis.
| Metastasis site | Characters | Metastasis at diagnosis | |||
|---|---|---|---|---|---|
| OR | 95% CI for HR | P | |||
| Lower | Higher | ||||
| Predictors of lung metastases | Renal pelvis [Ureter (reference)] | 1.67 | 1.32 | 2.14 | <0.001 |
| Clinical T stage [T4 vs. T1 (reference)] | 3.24 | 2.19 | 4.83 | <0.001 | |
| Clinical N stage [N1 vs. N0 (reference)] | 4.55 | 3.30 | 6.25 | <0.001 | |
| Clinical N stage [N2 vs. N0 (reference)] | 4.96 | 3.65 | 6.72 | <0.001 | |
| Clinical N stage [N3 vs. N0 (reference)] | 2.30 | 1.13 | 6.23 | 0.017 | |
| Size > 4 cm [≤2 cm (reference)] | 3.23 | 1.84 | 6.14 | <0.001 | |
| Predictors of bone metastases | Age > 80 years [≤60 years (reference)] | 0.53 | 0.35 | 0.80 | <0.001 |
| Size > 4cm [≤2cm (reference)] | 1.87 | 1.04 | 3.61 | 0.045 | |
| Clinical T stage [T2 vs. T1 (reference)] | 0.56 | 0.28 | 0.88 | 0.043 | |
| Clinical T stage [T4 vs. T1 (reference)] | 2.22 | 1.45 | 3.44 | <0.001 | |
| Clinical N stage [N1 vs. N0 (reference)] | 4.41 | 3.03 | 6.37 | 0.005 | |
| Clinical N stage [N2 vs. N0 (reference)] | 6.03 | 4.29 | 8.49 | <0.001 | |
| Clinical N stage [N3 vs. N0 (reference)] | 3.71 | 1.05 | 10.14 | 0.004 | |
| Predictors of liver metastases | Age > 80 years [≤60 years (reference)] | 0.67 | 0.43 | 0.94 | <0.001 |
| Size > 4 cm [≤2 cm (reference)] | 3.41 | 1.65 | 8.26 | 0.002 | |
| Grade high level [low level (reference)] | 2.05 | 1.01 | 4.93 | 0.044 | |
| Clinical T stage [T4 vs. T1 (reference)] | 2.63 | 1.66 | 4.23 | <0.001 | |
| Clinical N stage [N1 vs. N0 (reference)] | 4.51 | 3.03 | 6.69 | <0.001 | |
| Clinical N stage [N2 vs. N0 (reference)] | 5.36 | 3.53 | 7.81 | <0.001 | |
| Predictors of brain metastases | Age > 80 years [≤60 years (reference)] | 0.89 | 0.87 | 0.94 | 0.027 |
| Clinical N stage [N1 vs. N0 (reference)] | 6.58 | 2.02 | 22.15 | 0.001 | |
| Clinical N stage [N3 vs. N0 (reference)] | 11.71 | 5.82 | 18.34 | 0.031 | |
| Predictors of distant lymph node metastases | Size > 4 cm [≤2 cm (reference)] | 2.24 | 1.13 | 6.01 | 0.034 |
| Clinical N stage [N1 vs. N0 (reference)] | 3.41 | 2.55 | 7.33 | <0.001 | |
| Clinical N stage [N2 vs. N0 (reference)] | 5.24 | 3.27 | 8.27 | <0.001 | |
| Clinical N stage [N3 vs. N0 (reference)] | 5.98 | 3.58 | 9.43 | <0.001 | |
Abbreviations: OR, Odds Ratio; CI, Confidence Interval.