Fig. 10.

RNA nanoparticles stretched via dual trap optical tweezer by Guo and colleagues. (A) Dual trap optical tweezers with tethered RNA construct between two dsDNA handles via affinity linkers. (B) Control force–extension curve for stretching (red) and relaxing (black) of RNA nanoparticle as a square. Inset: Point at which the nanoparticle undergoes conformational change in response to force. [171] (C) RNA nanostructures constructed through using the dynamic property of pRNA 3WJ its natural angles of 97, 138, and 125 respectively, tunable past its these natural angles to 60°, 90°, and 108° respectively. [172] (A-B) Reprinted (adapted) with permission from Ghimire et al 2019. Copyright 2019 American Chemical Society. (C) Copyright 2014 Oxford University Press.