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Schematic of the effect of HIIT on protein expression. HIIT can act as a double-edged sword. HIIT, like resistance and endurance training, can activate and inactivate the mTOR pathway. Factors such as severity, duration, frequency, and the number of HIIT sessions are very influential. Activation of the mTORC1 pathway can activate factors such as P70S6K1 and 4E-BP1, which can increase protein synthesis, especially in diabetics
