Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 17;12:19791. doi: 10.1038/s41598-022-22214-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A) Affinity (K_D) changes of therapeutic COVID-19 antibodies and ACE2 in the presence of Delta (green) and Omicron BA.1 (red) spike RBDs as compared with wild type RBD. (B) K_D changes of therapeutic COVID-19 antibodies correlated with their published half-maximal effective concentrations (EC₅₀) or half-maximal inhibitory concentrations (IC₅₀) of focus reduction neutralization tests (FRNT; active virus) or pseudovirus neutralization tests (PNT), respectively. Triangles and diamonds are FRNTs using VERO-TMPRSS2 and VERO-hACE2-TMPRSS2 cells, respectively, taken from VanBlargan et al.⁷. Squares and circles are PNTs taken from Cao et al.⁵ and Liu et al.⁶, respectively. The solid line is a linear regression with the gray area indicating the 95% confidence intervals, R the Pearson’s correlation coefficient and the p-value demonstrating statistical significance. The dashed line indicates the ideal scenario of change in K_D being equal to change in EC₅₀ or IC₅₀.