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Examples of scaffolds that undergo liquid–liquid phase separation in cellular signaling
| Scaffold | Signaling pathway | Reference |
|---|---|---|
| NEMO | NF-κB | (46) |
| CIN85 | BCR | (129) |
| SLP-65 | BCR | (130) |
| LAT | TCR | (131, 132) |
| CTTNBP2 | Synaptic pathway | (65) |
| PSD-95 | Synaptic pathway | (64) |
| SHANK3 | Synaptic pathway | (65) |
| APC | Wnt/β-catenin | (133, 134) |
| Axin | Wnt/β-catenin | (133, 135) |
| TAZ | Hippo | (136) |
| RIα | cAMP-PKA | (137, 138) |
| p62 | Autophagy | (67) |
| NCK1 | Actin polymerization | (139) |
