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. 2022 Sep 30;15(1):39–59. doi: 10.1016/j.jcmgh.2022.09.013

Figure 6.

Figure 6

PRMT6 promotes inflammation and suppresses fibrosis. (A) Prmt6-deficient mice have lower levels of proinflammatory cytokines. Wild-type (WT), Prmt6+/- (Het), and Prmt6-/- (KO) mice were fed Western diet (WD, control) or WD with alcohol in the drinking water (WDA, alcohol) for 16 weeks. Relative mRNA levels. N = 4–8 per group. ∗P < .05, ∗∗P < .01. (B) WT and Prmt6-/- (KO) mice were injected with 2 mg/kg lipopolysaccharide. Blood was collected 6 hours after injection, and cytokine levels in serum were measured using Proteome Profiler Cytokine Array. Relative dot densities in WT vs KO. (C–E) WT, Prmt6+/- (Het), and Prmt6-/- (KO) mice were used to isolate hepatic stellate cells (HSC), Kupffer cells (KC), and endothelial cells (LSEC). Relative mRNA expression levels. N = 3–6 mice. ns, not significant. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, ∗∗∗∗P < .0001.