Figure S1.

(A) Circadian profiles of relative and quantitative abundance of bacterial families in Bmal1^SCNfl/- mice and their controls. (B) Heatmap illustrating the quantitative abundance of 412 zOTUs (mean relative abundance >0.1%; prevalence >10%). Data are ordered based on the zOTUs phase in the controls and normalized based in the peak of each zOTU. (C) Significance and amplitude (based on JTK_CYCLE) of all zOTUs (top) and phase (based on cosine regression) distribution (bottom) in both genotype, dashed line represents adj. p-value = 0.05 (JTK_CYCLE). (D) Taxonomic tree of zOTUs losing rhythmicity in Bmal1^SCNfl/- mice based on relative analyses. Taxonomic ranks were indicated as phylum (outer dashed ring), then family (inner circle) and genera (middle names), each zOTU represented by individual branches. (E) Circadian profile of relative abundance of example zOTUs losing rhythmicity in Bmal1^SCNfl/- mice. (F) Bar charts illustrate the alteration in abundance (adj. p-value ≤ 0.05) and fold change of zOTUs losing rhythmicity in Bmal1^SCNfl/- mice. Significant rhythms according to cosine-wave regression analysis (p-value ≤ 0.05) are visualized with a solid line, while data connected by dashed line indicate arrhythmicity. n = 6 mice/time point/genotype. Data are represented as mean ± SEM.