Table 3.

Types of the adverse effects and their severity according to CTCAE clasification.

Severity*	G1		G2		G3		G4
Type of AE	No. AE	No. patients	No.AE	No. patients	No.AE	No. patients	No. AE	No. patients
Fatigue	60	32	191	49	14	6	0	0
Diarrhea	106	66	77	58	43	14	23	3
Skin changes	110	38	11	8	5	4	0	0
Nausea	66	27	33	15	18	14	0	0
Vomiting	34	19	32	24	6	4	6	5
Fever	30	25	9	6	2	1	0	0
Others	266	76	197	28	30	12	0	0

AE, adverse effect;

^*CTCAE, common terminology criteria for adverse events.