Table 2.

Clinical staging of CUS

Stage	Symptoms
1	- Localized urticaria - Localized eczema/dermatitis - Non-specific symptoms (burning, itching)
2	- Generalized urticaria
3	- Systemic upper and lower airway and oropharyngeal manifestations (asthma, rhinitis, angioedema, lip swelling) - Systemic digestive manifestations (nausea, diarrhea) - Other allergic systemic manifestations (conjunctivitis)
4	- Generalized anaphylactic reaction, including anaphylactic shock